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Synthesis and Biological Activity of 3‐Methyl‐1 H ‐pyrazole‐4‐carboxylic Ester Derivatives
Author(s) -
Zhao WeiGuang,
Li ZhengMing,
Yuan PingWei,
Wang WenYan
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190213
Subject(s) - chemistry , pyrazole , biological activity , bioassay , proton nmr , organic chemistry , stereochemistry , in vitro , biochemistry , biology , genetics
In search of novel pyrazole derivatives with bioactivity, a series of 3‐methyl‐1 H ‐pyrazole‐4‐caboxylic: ester derivatives were synthesized via α‐oxoketene dithioacetals as starting material. The structures of all compounds prepared were confirmed by l H NMR, IR, MS and elemental analyses. Preliminary bioassays indicated that some compounds showed fungicidal activity against wheat rust, phoma asparagi and antiviral activity against TMV .