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Synthesis of Distamycin Analogs and Their Interactions with Calf Thymus DNA
Author(s) -
Xiao JunHua,
Yuan Gu,
Huang WeiQiang,
Du WeiHong,
Wang BaoHuai,
Li ZhiFen
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190121
Subject(s) - chemistry , dna , duplex (building) , stereochemistry , dna synthesis , coupling reaction , combinatorial chemistry , biochemistry , catalysis
Two distamycin analogs (PyPyPy‐γ‐Dp and PyPyPyPy‐γ‐Dp) were synthesized by a haloform reaction and the DCC/HOBT coupling reaction in a ample and fast way without amino protection. By using calf thymus DNA, the interaction between the analogs and DNA duplex was studied by CD, and ITC.