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Lipophilicity determination of N ‐( benzothiazol‐2‐yl )‐α‐amino alkyl phosphonic diesters by RP‐HPLC and RP‐HPTLC
Author(s) -
Zhang Luig,
Li ZaiGuo,
Huang RunQiu,
Wang QinSun
Publication year - 2000
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20000180614
Subject(s) - lipophilicity , chemistry , chromatography , high performance liquid chromatography , alkyl , methanol , thin layer chromatography , reversed phase chromatography , organic chemistry
Using methanol‐water mixtures as the mobile phase, the chromatographic retention parameters k' and R f were determined by reversed‐phase high‐performance liquid chromatography (RP‐HPLC) and reversed‐phase high‐performance thin‐layer chromatography (RP‐HPTLC) for N‐ (benzothiazol‐2‐yl)‐α‐amino alkyl phosphoric diesters and the correlation with lipophilicity parameter (Clog P ) was established. Log K w values obtained from RP‐HPLC and R m values obtained from RP‐HPTLC can be used to evaluate the lipophilicity of this kind of compounds. Chromatographic method is a good alternative for lipophilicity measurement.