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Polymeric bilayer modified microelectrodes for in‐vivo determination of neurotransmitter dopamine
Author(s) -
Yang LiJu,
Peng TuZbi,
Catherine Yang F.
Publication year - 2000
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20000180510
Subject(s) - chemistry , microelectrode , electrode , cyclic voltammetry , voltammetry , nafion , bilayer , electrochemistry , chemical engineering , membrane , biochemistry , engineering
A composite polymer carbon fiber electrode modified with Nafion and cellulose acetate is described. The modified electrode discriminates against both anionic reactants and big molecular organic compounds. The bilayer configuration is prepared in two steps. First, the carbon fiber electrode is coated with Nation, men followed by air evaporation of the solvent, me electrode is dipped in a cellulose acetate solution and hydrolyzed for a selected time. The permeability of the film is explored by use of rotating disk electrode measurements. Parameters affecting the film electrochemistry are investigated. The resulting electrodes show high selectivity and stability in body fluids. For in‐vivo voltammetry, the composite polymer modified electrode has been used for detection of me oxidative current of neurotransmitter dopamine in rat brain, while it inhabits the oxidation of an°C neurotransmitter metabolites and some electroactive compounds.