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Investigation of retention and chiral recognition mechanism using quantitative structure‐enantioselectivity retention relationship in high performance liquid chromatography
Author(s) -
Hui Chen,
XianYu Lu,
RuYu Gao,
JunMin Huang,
HuaZheng Yang,
QunSun Wang
Publication year - 2000
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20000180211
Subject(s) - chemistry , enantiomer , high performance liquid chromatography , chromatography , chiral stationary phase , isopropyl , retention time , chiral column chromatography , stereochemistry , medicinal chemistry
The enantiomers of a series of fourteen O ‐ethyl O ‐(substituted) phenyl N ‐isopropyl‐phosphoroamidothioates have been separated by high performance liquid chromatography (HPLC) on the Pirkle‐type chiral stationary phase. Seven molecular descriptors were calculated and four significant descriptors were chosen to correlate against the experimental ln k' values in order to form the quantitative structure‐enantioselectivity retention relationships (QSERRs). Through the QSERRs, the retention and enantioselectivity mechanism were examined.