Premium
Preparation of 9,13‐di cis double bonds locked retinoids
Author(s) -
FengLing Qing,
XiangJun Yue
Publication year - 2000
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20000180115
Subject(s) - chemistry , phosphonium salt , phosphonium , wittig reaction , double bond , aldehyde , bromide , carbonylation , thiophene , carbon monoxide , medicinal chemistry , cycloalkene , organic chemistry , salt (chemistry) , catalysis
Synthesis of two retinoids in which the 9, 13‐di cis double bonds were locked in cycloalkene or thiophene was described. The key steps were the Wittig olefination of phosphonium salt 3 and 23 with aldehyde 14, followed by carbonylation of vinyl bromide 17 and 24 with carbon monoxide in the presence of Pd(PPh 3 ) 4 .