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Interactions of oxidative radicals with N‐phosphoryl dipeptide derivatives
Author(s) -
GaoSheng Chu,,
JiaFu Chen,,
ZhiCheng Zhang,,
SiDe Yao,
Publication year - 1999
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19990170606
Subject(s) - chemistry , dipeptide , radical , radiolysis , intramolecular force , electron transfer , oxidative phosphorylation , photochemistry , peptide , stereochemistry , organic chemistry , biochemistry
The interactions of oxidative radicals (Br 2 − ‐, HO − etc .) with N‐phosphoryl dipeptide derivatives (NDM‐TrpOMe and NDT‐MetOMe) have been investigated by using pulse radiolysis at different pH values. It has been found that Br 2 − ‐ and HO − radicals oxidize the Met‐site and Trp‐site in the dipeptide derivatives via formation of the three‐electron‐bonded intermediate and indolyl radical simultaneously. Then the intramolecular electron transfer along the peptide backbone occurs. The rate constants of electron transfer, k , have been determined and the reaction mechanism has been deduced.