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Convenient one‐pot synthesis of functionalized cyclopentene via Sm/TMSCI/ t ‐BuOH system mediated hydrodimerization cyclization of gem‐diactivated alkene
Author(s) -
Wang Lei,
Zhang YongMin
Publication year - 1999
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19990170413
Subject(s) - chemistry , cyclopentene , alkene , combinatorial chemistry , medicinal chemistry , crystallization , organic chemistry , stereochemistry , catalysis
Functionalized cyclopentenes could be prepared through Sm/TMSCl/ t ‐BuOH mediated hydrodimerization cyclization of gem ‐diactivated alkene in one‐pot at room temperature. The trans‐ or trans , transform isomer is in the majority and the major product was isolated from its stereoisomers through the fractional crystallization method.