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Application of charge transfer reaction in the pharmaceutical analysis—Determination of chlorhexidine acetate
Author(s) -
Li HuaKan,
Zhao FengLin,
Tong ShenYang
Publication year - 1999
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19990170209
Subject(s) - chemistry , acetone , chlorhexidine , molar absorptivity , chloranil , chromatography , disinfectant , alcohol , nuclear chemistry , organic chemistry , medicine , physics , dentistry , optics
A spectrophotometric method for the determination of chlorhexidine acetate is described. The reaction between chlorhexidine acetate and chloranil took place in an alcohol‐acetone solution at room temperature. The composition of the charge transfer complex is 1:2. Beer's law is obeyed in the concentration range of 15–270 μg·mL −1 with correlation coefficient 0.9995. The apparent molar absorptivity is 2.21 × 10 3 L·mol −1 ·cm −1 at 412 nm. The method is accurate (with a recovery af 100 ± 1.6% ) and precise (RSD =1.0%). It was successfully applied to determine chlorhexidine acetate in suppository or disinfectant solution.