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Reactions of enamines with fluorinated acyl chlorides — Synthesis of fluorinated 1,3‐diketones and 1,3‐keto‐aldehydes
Author(s) -
HaiYing He,
YanLing Qu,
ChengXue Zhao
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160611
Subject(s) - chemistry , carbon atom , nucleophile , organic chemistry , carbon fibers , fluorine , medicinal chemistry , atom (system on chip) , acylation , acyl chloride , acyl group , catalysis , chloride , group (periodic table) , ring (chemistry) , materials science , composite number , computer science , composite material , embedded system
The reactions of enamines (1a–b, 4, 6) with fluorinated acyl chlorides (2a–d ) produced fluorinated 1,3‐diketones (3a–f) and 1,3‐keto‐aldehydes (7a–c) in good yields as well as byproducts fluorinated acylamides (5a–c). It is proposed that the reactions involve nucleophilic attack by the C‐atom and/or N‐atom of the enamines on acyl carbon of the fluorinated acyl chlorides.