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A practical synthesis of novel hydroxyl‐substituted macrocyclic tri‐, tetra‐ and hexa‐mines
Author(s) -
GuoPing Xue,
Yong Liu,
ChengTai Wu
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160609
Subject(s) - chemistry , diethylenetriamine , hexa , tetra , salt (chemistry) , medicinal chemistry , ring (chemistry) , condensation , organic chemistry , polymer chemistry , physics , thermodynamics
Macrocyclic tri‐ and tetra‐amines containing a hydroxyl group in the ring have been preparad in moderate yields by a 1:l cyclocondensation of 1,3‐dichloro‐2‐propanol with the disodium salt of N ‐tosylated diethylenetriamine and triethylenetetraamine. In the case of condensation of 1,3‐dichloro‐2‐propanol with the disodium salt of N ‐tosylated diethylenetriamine, the 2:2 cyclocondensation product, dihydroxyl macrocyclic hexaamine, was also isolated.