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Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor‐derived mercapto‐alcohols
Author(s) -
YongGui Zhou,
XueLong Hou,
LiXin Dai
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160314
Subject(s) - chemistry , camphor , borane , catalysis , organic chemistry , asymmetric induction , enantioselective synthesis , reduction (mathematics) , medicinal chemistry , geometry , mathematics
Easily available D ‐(+)‐camphor‐derived chiral mercapto‐alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2–72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved' when mercapto‐alcohols 2 and 3 were used.
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