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Organic solvent enhanced a‐helical formation of a nonadecapeptide derived from Trichosanthin (TCS 182–200)
Author(s) -
HongYu Hu,
ZiXian Lu,
YuCang Du
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160208
Subject(s) - chemistry , trichosanthin , circular dichroism , solvent , dielectric , alcohol , organic solvent , chirality (physics) , peptide , crystallography , organic chemistry , chemical engineering , biochemistry , physics , optoelectronics , engineering , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
A model peptide, TDK, was studied by circular dichroism to elucidate the effect of organic solvent on α‐helical formation. The a‐helicities enhanced by various alcohol solvents, especially fluorine‐substituted alcohols were systematically compared. The relations between a‐helical formation of a peptide and external environment were also discussed in detail. These environmental elements mainly include hydrophobicity, dielectric constant and acidity of the solvents.