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Design and synthesis of some new C 2 ‐symmetric chiral disulfonamides from aminoacids and the application in diethyl zinc addition to benzaldehyde
Author(s) -
JianQiang Wang,
Min Zhong,
GuoQiang Lin
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160111
Subject(s) - chemistry , benzaldehyde , zinc , reagent , ligand (biochemistry) , catalysis , chiral ligand , diethylzinc , medicinal chemistry , phenylalanine , valine , stereochemistry , enantioselective synthesis , organic chemistry , amino acid , receptor , biochemistry
Nine C 2 ‐symmetric chiral disulfonamides were designed and synthesized from L ‐valine, L ‐phenylalanine and L ‐leucine respectively via one‐pot ring opening of aziridines. The application of these disulfonamides as catalyst in the addition of diethyl zinc to benzaldehyde in three reagent systems: Ligand‐Ti(O i Pr) r ‐Et 2 Zn; Ligand‐Ti(O'Pr)d‐H z O‐Et 2 Zn; Ligand‐Et 2 Zn was also described.