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Asymmetric total synthesis of (+)‐1‐deoxy‐6‐ epi ‐castanospermine
Author(s) -
YiMing Xu,
WeiShan Zhou
Publication year - 1998
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19980160107
Subject(s) - chemistry , castanospermine , derivative (finance) , kinetic resolution , yield (engineering) , amine gas treating , stereochemistry , organic chemistry , medicinal chemistry , enantioselective synthesis , catalysis , enzyme , materials science , financial economics , economics , metallurgy
(+)‐l‐Deoxy‐6‐ epi ‐castanospermine was asymmetrically synthesized in ten steps from a‐furfuryl amine derivative 6 in 2.9% overall yield. The kinetic resolution of a‐furfuryl mine derivative 6 and Sharpless AD reaction of 14 were used as key steps.
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