Trichobitacin — a new ribosome‐inactivating protein I. The isolation, physicochemical and biological properties of trichobitacin | Zendy

Jin ShanWei | Zendy; Xiang BangPing | Zendy; Cao BaiXun | Zendy; Wang Yu | Zendy

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Trichobitacin — a new ribosome‐inactivating protein I. The isolation, physicochemical and biological properties of trichobitacin

Author(s) -

Jin ShanWei,

Xiang BangPing,

Cao BaiXun,

Wang Yu

Publication year - 1997

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.19970150211

Subject(s) - ribosome inactivating protein , chemistry , biochemistry , cucurbitaceae , ribosome , glycoprotein , rna , galactose , residue (chemistry) , botany , biology , gene

From the press‐residue of the fresh root tuber of Trichosanthes kirilowii Maim (Cucurbitaceae), a new ribosome‐inactivating protein (RIP), trichobitacin, was isolated. It has the activity of RNA N ‐glycosidase and can inhibit the growth of human placental trophoblastic cells. Its molecular weight is 27,228 Da (ES‐MS) and p I 9.6. It is a single chain basic RIP. Its amino acid composition was determined. It is a new RIP. It consists of 0.7∼0.9% galactose and may be a glycoprotein. Its N‐ and C ‐terminal amino acid is Asp and Ala, respectively. Its N ‐terminal preliminary amino acid sequence has been determined.

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