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Comparative studies on the mechanism of uridine phosphorolysis
Author(s) -
Zhao ShanRong,
Chen KaiXian,
Jiang HusLiang,
Wang QinMi,
Ji RuYun
Publication year - 1997
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19970150115
Subject(s) - phosphorolysis , chemistry , uridine , sn2 reaction , mechanism (biology) , transition state , stereochemistry , computational chemistry , catalysis , enzyme , organic chemistry , biochemistry , rna , purine nucleoside phosphorylase , philosophy , epistemology , purine , gene
We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid‐catalyzed Sn2 mechanism. The proposed reaction pathway is consistent with many experimental results.