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Synthesis, characterization, antitumor activity of nickel(II) and cobalt(II) complexes of 2,2′‐diamino‐4,4′‐bithiazole and their interaction with dGMP
Author(s) -
YanNi Tian,
Pin Yang,
QingShan Li,
ChunGui Zhao
Publication year - 1996
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19960140508
Subject(s) - chemistry , ethylenediamine , cobalt , nickel , molar conductivity , infrared spectroscopy , proton nmr , dna , stereochemistry , elemental analysis , nuclear chemistry , crystallography , inorganic chemistry , organic chemistry , biochemistry
New complexes, of bis(2,2′‐diamino‐4,4′‐bithiazole)sulfate nickel(II) and bis(2,2′‐diamino‐4,4′‐bithiazole)sulfate cobalt(II), have been prepared. The complexes were characterized by infrared and UV‐Vis spectroscopy, 1 H NMR, elemental analyses and molar conductivity. The effect of these complexes on the DNA synthesis of sarcoma 180 cells has been studied by the technique of isotopic liquid scintillation. The results indicated that complexes show ability to inhibit DNA synthesis of the tumor cells. In order to provide a molecular basis for understanding the biological effects, the probe, [ trans ‐en 2 Os( 2 ‐H 2 )](CF 3 SO 3 ) 2 (en, ethylenediamine) as a monitor was first used to explore interaction of the complexes with 2′‐deoxyguanosine‐5′‐monophosphate (dGMP).