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Determination of isoniazid and hydrazine by capillary electrophoresis with amperometric detection at a Pt‐particle modified carbon fiber microelectrode
Author(s) -
ErKang Wang,
WeiHong Zhou
Publication year - 1996
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19960140207
Subject(s) - chemistry , capillary electrophoresis , hydrazine (antidepressant) , amperometry , microelectrode , isoniazid , detection limit , electrode , capillary action , platinum , electrochemistry , particle (ecology) , chromatography , carbon paste electrode , analytical chemistry (journal) , cyclic voltammetry , organic chemistry , catalysis , materials science , composite material , medicine , tuberculosis , oceanography , pathology , geology
Capillary electrophoresis (CE)/electrochemical detection (EC) for the simultaneous determination of hydrazine and isoniazid has been developed. The electrochemical method uses a novel modified electrode dispersed with ultrafine platinum particles on the surface of a 30 μm carbon fiber microelectrode. The unique characteristic of the Pt‐particles modified carbon fiber microelectrode is its excellent stability. The current measurement for hydrazine is more sensitive than that of isoniazid. Selective determination of trace amount of free hydrazine in isoniazid and its formulation can be achieved at applied potential of 0.5 V.