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Integration of computer‐assisted statistical scanning optimization system in HPLC
Author(s) -
QinSun Wang,
RuYu Gao,
BingWen Yan
Publication year - 1996
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19960140108
Subject(s) - chemistry , simple (philosophy) , system optimization , high performance liquid chromatography , chromatography , biochemical engineering , mathematical optimization , philosophy , mathematics , epistemology , engineering
Three computer‐assisted statistical scanning methods, the monofactor optimization system (MOS), multicomponent solvent optimization system (MSOS), and difactor optimization system (DOS) for optimizing HPLC separations, have been integrated to produce the optimization system of HPLC (OS‐L). The method proposes the complementary use of these techniques, maximizing their strengths while compensating for their weaknesses. The result of OS‐L is a method development strategy which obtains simple solutions for simple separation problems and reserves the more complex solutions for difficult separations.