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Enantiomeric separation of α‐phenylethylamine and its derivatives by series coupled open tubular columns
Author(s) -
Zhou LiangMo,
Liu XueLiang,
Li ZhongSheng,
Wang QingHai,
Zhu DaoQian,
Hu DongHong
Publication year - 1995
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19950130509
Subject(s) - chemistry , enantiomer , series (stratigraphy) , enantiomeric excess , chromatography , analytical chemistry (journal) , stereochemistry , enantioselective synthesis , organic chemistry , catalysis , paleontology , biology
A series coupled fused‐silica open tubular columns of a chiral and an achiral stationary phase were used to achieve the enantiomeric separation of a‐phenylethylamine, o,m,p ‐methyl‐ and o,m,p‐ methoxy‐α‐phenylethylamine. A simplified equation describing the retention values of series coupled columns was derived, which relates the capacity factors of series coupled columns to the capacity factor of individual columns, their lengths, inlet and outlet pressure. Very good agreement was obtained both between calculated values by this equation and those by Krupcik's equation and between values measured experimentally and calculated theoretically. By means of this simplified equation a computer program was developed in locating the operating range of optimum α min , enantiomeric separation of all α‐phenylethylamine and its derivatives were achieved in a single run.