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Study on the stannous halides promoted addition of 1,1,1‐trichloro‐2,2,2‐trifluoroethane to aldehydes and the chemical transformation thereof
Author(s) -
Hu ChangMing,
Chen Jian
Publication year - 1994
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19940120213
Subject(s) - chemistry , reagent , halide , moiety , organic chemistry , medicinal chemistry , transformation (genetics) , biochemistry , gene
Promoted by stannous salts, 1,1,1‐trichloro‐2,2,2‐trifluoroethane reacts readily with aliphatic, aromatic, and α,β‐unsaturated aldehydes giving the corresponding alcohols bearing a CF 3 CCl 2 ‐moiety in good to excellent yields. These alcohols are further oxidized by Jones reagent giving the corresponding ketones in high yields.