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The correlation between molecular structure parameters of O ‐ethyl N ‐isopropyl phosphoro(thioureido) thioates and their retention data in RP‐HPLC
Author(s) -
Wang QinSun,
Gao RuYu,
Yang HuaZheng,
Yan BingWen
Publication year - 1993
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19930110112
Subject(s) - chemistry , substituent , isopropyl , high performance liquid chromatography , chromatography , selectivity , phase (matter) , kovats retention index , solvent , analytical chemistry (journal) , stereochemistry , organic chemistry , gas chromatography , catalysis
A retention prediction system (RPS) of seven O ‐ethyl N ‐isopropyl phosphoro(thioureido)‐thioates in reversed phase HPLC was investigated. The system is based on the solvent selectivity triangle concept. Three molecular structure parameters (hydrophobicity II , substituent length L , and substituent maximum with B 5 ) were used to describe the quantitative structure‐retention relationships. With these quantitative relationships, the retention behaviours of other eight homologs for different mobile phase composition were predicted. The predicted values were consistent with the measured values within relative error of 10%, which means that it is possible to apply the reported method to predict retention values for qualitative purposes for different mobile phase compositions.