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Studies on the synthesis of amino acids XIII. Dibenzylation of 2‐phenyl‐2‐oxazolin‐5‐one
Author(s) -
Du ZhengMing,
Chen JiJun,
Shi YaoZeng,
Hu HongWen
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100614
Subject(s) - chemistry , hydrolysis , amino acid , medicinal chemistry , organic chemistry , biochemistry
4,4‐Dibenzyl‐2‐phenyl‐2‐oxazollin‐5‐ones are prepared by one step reaction of 2‐phenyl‐2‐oxazolin‐5‐one with magnesium methyl carbonate (MMC) and benzylhalides. It is a novel and convenient method for the synthesis of α,α ‐disubstituted α‐amino acids by hydrolysis of 4,4‐dibenzyl‐2‐phenyl‐2‐oxazolin‐5‐ones.