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Kinetics of zinc and cadmium dissociation of metallothionein in the presence of chelating agents
Author(s) -
Huang ZhongXian,
Hu HongYu,
Gu WeiQiang
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100605
Subject(s) - chemistry , metallothionein , kinetics , chelation , dissociation (chemistry) , cadmium , zinc , metal , metal ions in aqueous solution , amino acid , penicillamine , inorganic chemistry , biochemistry , organic chemistry , physics , quantum mechanics
The dissociation kinetics of metal ions from native metallothionein (Cd 5 Zn 2 ‐MT) of rat liver has been studied in the presence of external ligands including amino acids, peptide and polyamino polycarboxylic acids at 25°C. The study shows that the solution pH affects the metal dissociation process. Different ligands present different multiphasic kinetics. The possible mechanism of metal dissociation from metallothionein has been proposed.