Synthesis and reactions of some 6‐aryl and 2,6‐diaryl‐4‐(4′‐antipyrinyl)‐2,3,4,5‐tetrahydropyridazin‐3‐ones and screening for their antibacterial activities | Zendy

Sayed G. H. | Zendy; Shiba S. A. | Zendy; Radwan A. | Zendy; Mohamed S. M. | Zendy; Khalil M. | Zendy

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Synthesis and reactions of some 6‐aryl and 2,6‐diaryl‐4‐(4′‐antipyrinyl)‐2,3,4,5‐tetrahydropyridazin‐3‐ones and screening for their antibacterial activities

Author(s) -

Sayed G. H.,

Shiba S. A.,

Radwan A.,

Mohamed S. M.,

Khalil M.

Publication year - 1992

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.19920100515

Subject(s) - chemistry , phenylhydrazine , thiourea , benzoyl chloride , pyridazine , pyridine , aryl , ethyl bromoacetate , organic chemistry , chloride , ethanol , antibacterial activity , hydrazine (antidepressant) , oxime , medicinal chemistry , adduct , combinatorial chemistry , alkyl , biology , bacteria , genetics , chromatography

Some new pyridazinone derivatives(3) were synthesized through addition of antipyrin to β‐aroylacrylic acids (1) followed by cyclization of the adducts. Reactions of 3 with ethyl bromoacetate, benzenesulfonyl chloride, benzoyl chloride and POCl 3 give N ‐substituted products and monochlorosubstituted pyridazines (4), respectively. The reactions of the latter with thiourea give unexpected dithio‐derivatives (5), which react with phenylhydrazine to give pyrazolopyridazino pyridazine derivatives (6). Reactions of 2 with NH 2 OH in ethanol and pyridine afford oxime and oxazinone derivatives 7 and 8, respectively. The antibacterial activities of several compounds were screened.

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