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Kinetics of tautomerization of 1,3,4,7‐tetramethylisoindole
Author(s) -
Capon B.,
Ying BaiNing
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100211
Subject(s) - chemistry , isoindole , tautomer , kinetics , kinetic isotope effect , deuterium , transformation (genetics) , oxide , solvent , photochemistry , medicinal chemistry , organic chemistry , biochemistry , physics , quantum mechanics , gene
Abstract The kinetics of transformation of 1,3,4,7‐tetramethylisoindole ( 1 ) to 1,3,4,7‐tetramethyl‐1 H −isoindole ( 2 ) in water or in deuterium oxide at various pH or pD at 25°C were measured spectrophotometrically. The results indicated that the transformation of 1 to 2 could be promoted by acid and base. From the solvent isotope effects and the fact that the 1‐position of isoindole nucleus is electron‐rich, the mechanism of this transformation is suggested.