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Studies on the synthesis of amino acids XII. Solid‐liquid phase transfer catalytic dicondensation of 1,4‐diacetyl‐2,5‐piperazinedione with aldehydes
Author(s) -
Du ZhengMing,
Zhou XiaoMing,
Shi YaoZeng,
Hu HongWen
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100114
Subject(s) - chemistry , catalysis , diacetyl , hydrochloric acid , phase (matter) , zinc , organic chemistry , nuclear chemistry
3,6‐Diarylidene‐2,5‐piperazinediones ( 2 ) and 3‐alkylidene‐6‐arylidene‐2,5‐piperazinediones ( 6 ) were synthesized from diacetyl‐2,5‐piperazinedione ( 1 ) under solid‐liquid phase transfer catalytic conditions. 2 could be easily convered to α‐amino acid by reducing with zinc powder and hydrolyzing with concentrated hydrochloric acid. The effect of different phase transfer catalysts and reaction conditions were studied.