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Studies on condensed heterocyclic compounds II. Synthesis and antibacterial activity of 3‐(4′‐pyridyl)‐6‐aroylamino/arylamino‐ S ‐triazolo[3,4‐ b ]‐1,3,4‐thiadiazoles
Author(s) -
Zhang ZiYi,
Chen Xin
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100111
Subject(s) - chemistry , thiadiazoles , triethylamine , isothiocyanate , antibacterial activity , yield (engineering) , triazole , phenyl isothiocyanate , medicinal chemistry , stereochemistry , organic chemistry , bacteria , materials science , biology , metallurgy , genetics
3‐(4′‐Pyridyl)‐4‐amino‐5‐mercapto‐1,2,4‐triazole (1) reacted with aroyl isothiocyanates 2a‐1 to yield twelve novel 3‐(4′‐pyridyl)‐6‐aroylamino‐ S ‐triazolo [3,4‐ b ]‐1,3,4‐thiadiazoles, 4a‐1 . Triethylamine was necessary for the condensation of 1 with phenyl isothiocyanate ( 3 ) to give 3‐(4′‐ pyridyl)‐6‐phenylamino‐ S ‐triazolo [3,4‐ b ]‐1,3,4‐thiadiazole ( 6 ). The structures were confirmed by the elemental and spectral analyses. Their antibacterial activity against B . Subtilis, E. Coli, E. aerogenes and S. aureus was observed preliminary.