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A novel method for the synthesis of carba‐DHPG and carba‐ACV
Author(s) -
Liu YuGang,
Fei ChangPei,
Chen TeHeng,
Chan TaHang
Publication year - 1991
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19910090609
Subject(s) - chemistry , regioselectivity , yield (engineering) , combinatorial chemistry , catalysis , organic chemistry , materials science , metallurgy
A new and efficient method for the synthesis of potential antiviral agents Carba‐ACV (3) and Carba‐DHPG (4) is described. The synthesis makes the use of N ‐acetylguanine to condense with the corresponding tosylates (16) and (11) under the catalysis of dibenzo‐18‐C‐6, resulting in the desired coupling products (17) and (12) in good yield and in the case of Carba‐DHPG with high regioselectivity.