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Synthesis of substituted pyrazolo [1,5 — a ] pyrimidines
Author(s) -
Deeb A.,
ElMobayed M.,
Essawy A.,
ElHamid Abd A.,
Abd ElHamid M. Atef
Publication year - 1991
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19910090517
Subject(s) - chemistry , diethyl malonate , acetylacetone , pyrimidine , ethyl cyanoacetate , ring (chemistry) , malonate , condensation , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , malononitrile , catalysis , physics , thermodynamics
Condensation of 3‐amino‐4‐cyanopyrazole (1) with ethylacetoacetate, ethyl cyanoacetate, diethyl malonate and acetylacetone afforded pyrazolo[1,5‐ a ]pyrimidine derivatives (2—8a). Other compounds (8b—h) of this ring system were obtained by treatment of 1 with arylidenemalononitrile and ethylarylidenecyanoacetate. And the reaction of compound (1) with activated acetylenes yeilded pyrazolo[1,5‐ a ]pyrimidine derivatives (11a—b).