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Studies on sulfinatodehalogenation XIII. Synthesis of 2‐perfluoroalkyl‐2‐deoxy‐ D ‐glucose, mono‐ and poly‐ O ‐polyfluoroalkylated‐ D ‐glucoses
Author(s) -
Huang WeiYuan,
Xie Yuan
Publication year - 1991
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19910090410
Subject(s) - chemistry , sodium dithionite , d glucose , medicinal chemistry , sodium , stereochemistry , organic chemistry
Sodium dithionite‐initiated addition of R F I (1) [R F =1a, Cl(CF 2 ) 4 ; 1b, Cl(CF 2 ) 6 ; 1c, Cl(CF 2 ) 6 ; 1d, n ‐C 6 F 13 ; 1e, n ‐C 3 F 17 ] to the properly protected glucose derivatives 2, 9, 12 and 15 gave polyfluoroalkylated glucose derivatives 7, 11, 14 and 17 respectively in good yields after reduction and deprotection. These compounds are strongly surface active.