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Palladium‐catalyzed cross‐coupling reaction of phenyl fluoroalkanesulfonates with organometallics
Author(s) -
QingYun Chen,
YaBo He
Publication year - 1990
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19900080511
Subject(s) - chemistry , palladium , regioselectivity , catalysis , reagent , coupling reaction , oxidative addition , lithium (medication) , organic chemistry , alkylbenzenes , medicinal chemistry , combinatorial chemistry , medicine , endocrinology
The palladium‐catalyzed cross‐coupling reaction of phenyl fluoroalkanesulfonates with organozinc, organotin and organoaluminum reagents in the presence of lithium chloride takes place to afford alkylbenzenes in good yields. However, the coupling reaction with organolithium and Grignard reagents proceeds unsatisfactorily with poor regioselectivity. On the basis of the isolation of an oxidative addition product of phenyl fluoroalkanesulfonate to palladium, a catalytic cycle in the reaction is suggested.