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Stability of ternary amino acid complexes and its computer simulation under physiological conditions
Author(s) -
ZhongXian Huang,
XiaoYin Dai,
Xiao Hua,
Xu Chang
Publication year - 1990
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19900080207
Subject(s) - chemistry , hsab theory , ternary operation , lewis acids and bases , amino acid , zinc , ternary complex , stability constants of complexes , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , ion , enzyme , computer science , programming language
The binary and ternary formation constants of mixed amino acid complexes with Zn(II), Cu(II), Ni(II) and Cd(II) have been potentiometrically determined under physiological conditions. The symbiosis of HSAB does play a role in the formation of ternary amino acid complexes. Comparing with Zn(II), as a softer Lewis acid Ni(II) shows its preference to softer Lewis bases cysteinate and histidinate. These soft Lewis bases more likely gather together in the mixed amino acid complexes. It is expected that the ternary amino acid complexes are overwhelming in the distribution of complex species especially at biological conditions. In the case of zinc, differring from previous study the alaninate‐containing mixed complexes become the predominant species formed in the region of pH 7.4.