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Synthesis of cross‐linked polystyrene‐supported polyethylene glycol and investigation of its property in peptide synthesis
Author(s) -
Ying Jiang,
Xun Liang,
WeiZhu Chen,
BingLin He
Publication year - 1988
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19880060408
Subject(s) - chemistry , polyethylene glycol , polymer chemistry , peg ratio , polystyrene , copolymer , divinylbenzene , condensation reaction , styrene , peptide synthesis , sodium hydroxide , grafting , peptide , polymer , organic chemistry , catalysis , biochemistry , finance , economics
Abstract The polyethylene glycol resin (PEG‐Resin) which possesses hydrophilic properties was prepared by grafting the polyethylene glycol onto the chloromethylated copolymer of styrene and divinylbenzene in the presence of concentrated sodium hydroxide solution. The proceeding of the graft reaction was identified by IR spectrum analysis. There factors which affected the grafting reactions were investigated. By using the PEG‐Resin polymer support, we compared the reactions for the syntheses of a tetra‐peptide and a penta‐peptide with the Merrifield solid peptide synthesis. We also measured the reaction kinetics of these reactions. The experimental results showed that by employing the PEG‐Resin, the reaction rates and condensation yields of these peptide syntheses were improved.