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The nucleophilic reaction of polyfluoroaromatic compounds: II. The nucleophilic cyclization of chloropentafluorobenzene
Author(s) -
WenZheng Ge,
LiQing Hu,
WeiYuan Huang
Publication year - 1988
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19880060309
Subject(s) - chemistry , nucleophile , bifunctional , reagent , medicinal chemistry , sodium , organic chemistry , catalysis
The results of cyclization reaction between chloropentafluorobenzene and bifunctional nucleophiles such as XCH 2 CH 2 OH(X=OH, NHMe, NHEt) and HN (CH 2 CH 2 OH) 2 , NH 2 CH 2 CH 2 NH 2 were reported. It was found that the NaH/DMF system was a better reagent for the preparation of sodium alcoholates and the yields of cyclic products ranged from 50–80% which were much higher than that reported by previous workers. 3
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