Premium
Study of caged bicyclic phosphorus: I. 1‐Oxo‐4‐substituted‐2,6,7‐trioxa‐1‐phosphabicyclo[2,2,2]‐octane and its reaction
Author(s) -
YuGui Li,
JianJi Wang,
Tao Han,
YunShan Liu,
JinHong Cao,
XiaoChun Jiang,
FangMing Miao,
XiaoLan Liu
Publication year - 1988
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19880060305
Subject(s) - chemistry , octane , hydroxymethyl , medicinal chemistry , bicyclic molecule , phenols , nitric acid , chloride , organic chemistry
1‐Oxo‐4‐hydroxymethyl‐2,6,7‐trioxa‐1‐phosphabicyclo[2,2,2]octane ( 1 ) is oxidized by concentrated nitric acid to the corresponding acid 2. From the reaction of the acid chloride 3 with various phenols and aryl amines two series of new bicyclophosphates 4 and 5 have been prepared. The reduction of 4b with iron powder in HOAC gave the O→N acyl‐migration product 4s. The crystal structure of 4n was determined by X‐ray diffraction analysis.