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Total synthesis of (±)‐fangchinoline
Author(s) -
DingAn Deng,
BaiChaun Pan
Publication year - 1986
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19860040109
Subject(s) - chemistry , tetrahydroisoquinoline , potassium carbonate , pyridine , potassium , condensation , stereochemistry , medicinal chemistry , organic chemistry , physics , thermodynamics
(±)‐Fangchinoline was synthesized by condensation of (±)‐1‐(3‐bromo‐4‐methoxy‐benzyl)‐2‐methyl‐6‐methoxy‐7‐hydroxy‐8‐bromo‐1,2,3,4‐tetrahydroisoquinoline ( 2 ) and (±)‐1‐(4‐hydroxy‐benzyl)‐2‐methyl‐6‐methoxy‐7‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline ( 3 ) in the presence of copper, pyridine and potassium carbonate.
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