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The thermodynamic investigation of inclusion complexations between β—cyclodextrin and hyoscyamine drugs
Author(s) -
CuiQing Hu
Publication year - 1985
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19850030102
Subject(s) - chemistry , cyclodextrin , steric effects , inclusion compound , inclusion (mineral) , molecule , hydrophobic effect , chirality (physics) , stability constants of complexes , stereochemistry , organic chemistry , computational chemistry , aqueous solution , mineralogy , nambu–jona lasinio model , chiral symmetry breaking , quantum mechanics , quark , physics
The inclusion complexations of β‐cyclodextrin with four hyoscyamine drugs were investigated by microcalorimetric technique and 1 HNMR. All the inclusion complexes were found to be 1:1 and their thermodynamic parameters of formation constant K , Δ G° , Δ H° and Δ S° were obtained. The 1 HNMR spectra strongly suggested that the drug molecule is included in the hydrophobic cavity of β‐cyclodextrin. The properties of binding force and effects of steric hindrance and chirality of the drugs on the inclusion complexation were also discussed.