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Chemical transformations of arteannuin B
Author(s) -
YuanZhu Gai,
YaPing Zheng,
LiangQuan Li
Publication year - 1983
Publication title -
acta chimica sinica english edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 0256-7660
DOI - 10.1002/cjoc.19830010106
Subject(s) - chemistry , boron trifluoride , saponification , deoxygenation , potassium hydroxide , artemisia annua , organic chemistry , medicinal chemistry , catalysis , artemisinin , malaria , immunology , plasmodium falciparum , biology
Using arteannuin B (2) isolated from Artemisia annua L.,a number of chemical transformations have been carried out, i.e. , catalytic hydrogenation of 2 to give a mixture of 5, 6 and 7, reaction of 6 with boron trifluoride etherate to give 8 and 9, saponification of 6 with potassium hydroxide and deoxygenation of 2, 6 and 7 with iron pentacarbonyl to give 18, 4 and 3, respectively.
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