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Video analysis of submerged jet microencapsulation using HEMA‐MMA
Author(s) -
Stegemann Jan P.,
Sefton Michael V.
Publication year - 1996
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450740412
Subject(s) - hexadecane , precipitation , materials science , jet (fluid) , aqueous solution , chemical engineering , eccentricity (behavior) , layer (electronics) , composite material , phase (matter) , limiting , copolymer , chromatography , chemistry , organic chemistry , mechanics , polymer , physics , political science , law , mechanical engineering , engineering , meteorology
Video and digital image analysis were used to understand the limiting steps in a submerged jet microencapsulation process for mammalian cells. Hydroxyethylmethacrylate‐methylmethacrylate copolymer (HEMA‐MMA) two phase droplets with an aqueous core are formed by coextrusion at a needle tip and fall through a layer of hexadecane prior to precipitation in an aqueous medium. Initial eccentricity was lowest when the capsule cores contained 20% (w/v) Ficoll and the inner needle protruded 100 m̈m past the outer needle. Capsule morphology was refined in the hexadecane over‐layer, and was strongly affected by crossing the hexadecane‐precipitation bath interface.