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Insect cell cultivation techniques for the production of high‐valued products
Author(s) -
Goosen Mattheus F. A.
Publication year - 1991
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450690208
Subject(s) - suspension culture , bioproducts , insect , microbiology and biotechnology , cell culture , biology , biochemical engineering , botany , engineering , genetics , biofuel
The large scale cultivation of insect cells will likely play an increasingly important role for the commercial production of bioproducts. While much research work has been done on the engineering aspects of insect cell suspension culture, many questions remain unanswered (i.e. the nature of bubble damage in sparged reactors, shear sensitivity and adaptation of cells; the use of serum‐free medium). In addition, insect cell immobilization may become a suitable technique for enhancing cell densities and product concentrations. This article presents a brief critical review of the development of insect cell suspension culture techniques for the production of insect pathogenic viruses and recombinant proteins.The problems of culturing microencapsulated insect cells, infected with a temperature sensitive baculovirus, also is discussed.