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An industrial cell biologist's wish list
Author(s) -
Seaver Sally S.
Publication year - 1991
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450690202
Subject(s) - biologist , productivity , bioreactor , biochemical engineering , work (physics) , production (economics) , computer science , microbiology and biotechnology , biology , engineering , genetics , mechanical engineering , botany , economics , macroeconomics
The current state of protein production by eukaryotic cells in culture is reviewed by a cell biologist with an eye towards areas that could benefit from more work by chemical engineers. The basic question of how the type of bioreactor influences cell productivity has not been answered. We are still learning how to optimize protein production in all types of bioreactors. Recent examples show that optimization can increase productivity over 10‐fold. Support work needs to be done to determine the limits of individual cell productivity. Basic cell metabolism work needs to be done in serum‐free medium to make it generally applicable. Only then can better bioreactors be designed with useful probes to monitor important substances.