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Computer control of continuous immobilized cell penicillin fermentations: Simulation studies
Author(s) -
Kalogerakis Nicolas,
Unardos Theodor,
Behie Leo A.,
Svrcek William Y.,
Gaucher G. Maurice
Publication year - 1986
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450640408
Subject(s) - penicillin , bioreactor , fermentation , process engineering , effluent , biochemical engineering , process (computing) , computer science , microbiology and biotechnology , chemistry , antibiotics , waste management , engineering , biology , food science , biochemistry , organic chemistry , operating system
Immobilized cell technology provides a simple and promising alternative to submerged free cell fermentations for the production of antibiotics like penicillin‐G. Recently, our biotechnology group has successfully developed a three phase fluidized bed bioreactor that is capable of running in a continuous mode more than 600 h. As a direct follow‐up, we propose in this paper a simple process control system which will enable penicillin fermentations to run under any desired cell specific growth rate and penicillin concentration in the effluent stream. By implementing such a control scheme, the reactor productivity can be substantially increased, and hence, make continuous fermentations highly attractive economically.