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The production of the antibiotic patulin in a three phase fluidized bed reactor: II. Longevity of the biocatalyst
Author(s) -
Berk Dimitrios,
Behie Leo A.,
Jones Alan,
Lesser Barry H.,
Maurice Gaucher G.
Publication year - 1984
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450620119
Subject(s) - patulin , fluidized bed , chemistry , food science , longevity , phase (matter) , chromatography , microbiology and biotechnology , biology , organic chemistry , mycotoxin , genetics
The longevity of the enzyme system for the production of the antibiotic patulin by immobilized Penicillium urticae cells was studied in a three phase fluidized bed reactor. Calculation of the global rate of patulin production indicated that, if the cells were not allowed to grow, the production of patulin gradually declined and stopped at 320 h. Intermittent pulse additions of nutrients stimulated the slow growth of the cells and resulted in an extended production time of 525 h. This long term production was the result of the formation of new cells rather than the maintenance of the original ones.