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Guidelines for the optimal design of experiments to estimate parameters in first order kinetic models
Author(s) -
Reilly Park M.,
Bajramovic R.,
Blau G. E.,
Branson D. R.,
Sauerhoff M. W.
Publication year - 1977
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450550521
Subject(s) - kinetic energy , design of experiments , mathematics , optimal design , fish <actinopterygii> , bioconcentration , type (biology) , experimental data , constant (computer programming) , statistical hypothesis testing , mathematical optimization , computer science , statistics , chemistry , physics , ecology , bioaccumulation , organic chemistry , quantum mechanics , fishery , biology , programming language
The optimal designs for experiments to estimate velocity and equilibrium constants in first order chemical kinetic situations are examined. Equations and charts which choose optimal designs are presented. A bioconcentration test using fish as the test organism is used to illustrate the problem and some good experiments of this type performed in the past are compared for efficiency with the corresponding optimal ones. Examples are also given of the statistical analysis of this type of experiment.