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Simulation and experimental analysis of an intelligent tissue for controlled drug delivery
Author(s) -
Barati Aboulfazl,
Sotoudeh Saman,
Davarnejad Reza,
Farahani Mohammad Aliabadi
Publication year - 2011
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.20634
Subject(s) - self healing hydrogels , swelling , polyethylene glycol , drug delivery , acrylamide , peg ratio , acrylic acid , materials science , diffusion , biomedical engineering , drug , chemistry , chemical engineering , polymer chemistry , composite material , polymer , nanotechnology , pharmacology , monomer , organic chemistry , thermodynamics , physics , medicine , engineering , finance , economics
In this research, an antibiotic was loaded in the composites of polyethylene glycol (PEG), acrylamide (AAm) and acrylic acid (AAc) hydrogels matrices and their drug deliveries were tested. Effect of some parameters on the drug delivery was checked by UV‐spectrophotometer. Temperature enhancement considerably increased hydrogel swelling and the drug release in the AAc and AAm. A dynamic model based on the Maxwell–Stefan equation was developed to model the drug delivery of hydrogels. COMSOL software was also applied to simulate buffer diffusion inside the hydrogels.