Premium
Combination of synthetic peptides derived from bone morphogenetic proteins and biomaterials for medical applications
Author(s) -
Senta H.,
Bergeron E.,
Drevelle O.,
Park H.,
Faucheux N.
Publication year - 2011
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.20453
Subject(s) - extracellular matrix , bone morphogenetic protein , bone healing , bone morphogenetic protein 2 , microbiology and biotechnology , bone matrix , bone morphogenetic protein 7 , chemistry , materials science , biomedical engineering , biochemistry , anatomy , biology , medicine , in vitro , cartilage , gene
A critical‐size bone defect cannot repair itself. These defects are presently filled by bone grafts or with biomaterials that mimic bone properties. The activity of bone cells is modulated by cytokines like the bone morphogenetic proteins (BMPs). This review described the peptides derived from BMPs or extracellular matrix proteins which can be immobilised on biomaterials to increase their action on bone cells and promote healing. However, the development of such materials requires peptides that can act in synergy. This requires the use of model surfaces to better understand how cells perceive biomaterials.