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Precipitation of pharmaceuticals using a supercritical anti‐solvent (SAS) dechnique: A preliminary study
Author(s) -
Imsanguan Photchanathip,
Yanothai Tanawan,
Pongamphai Suwassa,
Douglas Supaporn,
Teppaitoon Wittaya,
Douglas Peter L.
Publication year - 2011
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.20427
Subject(s) - particle size , precipitation , supercritical fluid , particle size distribution , andrographolide , scanning electron microscope , yield (engineering) , materials science , solvent , morphology (biology) , analytical chemistry (journal) , particle (ecology) , chemical engineering , chromatography , chemistry , mineralogy , metallurgy , organic chemistry , composite material , meteorology , physics , biology , engineering , genetics , oceanography , geology
The aims of this research were to investigate the applicability of the supercritical anti‐solvent (SAS) process on the precipitation of pharmaceuticals (andrographolide and acetaminophen). In particular, the goal of this research was to study the influence of pressure at 10 and 24 MPa on particle characteristics (morphology, crystalline structure, polymorphic form, size, size distribution, and precipitation yield), and to compare the precipitation efficiency of SAS process and evaporation process. Scanning electron microscope (SEM), X‐ray diffraction (XRD), and high performance liquid chromatography (HPLC) showed a significant change in particle size, size distribution, morphology, and precipitation yield, respectively. From an analysis of the results it was found that the crystal size of andrographolide and acetaminophen decreased with increasing pressure. The morphology of andrographolide particles changed from slice‐like to column‐like when the pressure was increased. On the other hand, the acetaminophen particles obtained were found to be monoclinic form (I) under both operating pressures. The SAS process produced small uniform shaped crystals, with a narrow size distribution, high precipitation yield and selective precipitation were also observed.