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A new method for the detection of microorganisms in blood cultures: Part I. Theoretical analysis and simulation of blood culture processes
Author(s) -
Smith Jennifer M.,
Serebrennikova Yulia M.,
Huffman Debra E.,
Leparc German F.,
GarcíaRubio Luis H.
Publication year - 2008
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.20095
Subject(s) - microorganism , biochemical engineering , reflectivity , human blood , blood culture , biological system , computer science , chemistry , process engineering , bacteria , microbiology and biotechnology , biology , physiology , optics , engineering , physics , genetics , antibiotics
The physical and chemical changes occurring in blood as a consequence of microbial activity can be used as quantitative indicators of the presence of microorganisms in blood cultures. This paper reports on the theoretical analysis and computer simulation of the changes in the physical and chemical properties of blood expected as a result of the presence of microorganisms and explores the possibilities of spectrophotometric systems for the early detection of pathogens. It is concluded that multi‐wavelength reflectance methods are suitable and that the approach reported herein can lead to considerable simplifications and cost reduction of blood culture systems.